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Título Immunomodulating drugs / edited by Vassil St. Georgiev and Hideyo Yamaguchi

Publicación New York : New York Academy of Sciences, 1993
Ubicación Signatura Tipo de préstamo Estado Notas
 Ciencias.Física/Química-Bioquímica y Biología Molecular y Celular  BQ Anel-34    CONSULTAR DEPT  DISPONIBLE
Descripción física XVI, 816 p. : il. ; 24 cm
Colección Annals of the New York Academy of Sciences, ISSN 0077-8923 ; 685
Annals of the New York Academy of Sciences ; 685
Nota "This volume is the result of a conference ... held by the New York Academy of Sciences on June 27-July 1, 1992 in Washington, D.C."--P. v.
Bibliografía Bibliografía por capítulos. -- Índices p. 813-816
Contiene: Preface ━ Part I. FK‐506: Chemistry and Biological Evaluation: Immunomodulating Drugs: Major Advances in Research and Development -- FK‐506: Its Role in Immunosuppression -- Discovery of FK‐506 and Update -- FK‐506–A Novel Immunosuppressant -- Structural Studies of Complexed FK‐506 Binding Protein -- Allograft and Xenograft Acceptance under FK‐506 and Other Immunosuppressant Treatment -- FK‐506 Inhibits the IL‐2‐Independent Induction of the Activation Antigen CD 69 -- Comparison of FK‐506, Rapamycin, Ascomycin, and Cyclosporine in Mouse Models of Host‐versus‐Graft Disease and Heterotopic Heart Transplantation ━ Part II. Immunosuppressive Properties of Rapamycin Rapamycin: In Vitro Profile of a New Immunosuppressive Macrolide -- Prevention and Treatment of Allograft Rejection in Vivo by Rapamycin: Molecular and Cellular Mechanisms of Action -- Rapamycin Prolongs Survival of Murine Recipients of Fully Allogeneic Donor Grafts When Administered during the Graft‐versus‐Host Disease Process -- Effects of Orally Administered Rapamycin in Animal Models of Arthritis and Other Autoimmune Diseases -- Rapamycin's Inhibition of Thymocyte Proliferation, Unlike That of Cyclosporin A or Prednisolone, Is Not Associated with Cytotoxicity -- Rapamycin's Inhibition Lymphocyte Proliferation in a Poplked Lymph Node Model via an IL‐2‐Independent Mechanism -- Rapamycin in a Porcine Renal Transplant Model
━ Part III. 15‐Deoxyspergualin: Chemistry and Immunosuppressive Action: Synthesis and Background Chemistry of 15‐Deoxyspergualin -- 15‐Deoxyspergualin, a Novel Immunosuppressive Drug: Studies of the Mechanism of Action -- Successful Treatment with a Novel Immunosuppressive Agent, Deoxyspergualin, in Type II Collagen‐Induced Arthritis in Mice -- Preclinical Studies with 15‐Deoxyspergualin in Various Animal Models for Autoimmune Diseases -- 15‐Deoxyspergualin: A Novel Immunosuppressive Drug with Clinical Potential -- Deoxyspergualin in Allogeneic Kidney and Xenogeneic Islet Transplantation: Early Clinical Trials -- Deoxyspergualin: Clinical Trials in Renal Graft Rejection -- A Member of the Hsp70 Family of Heat‐Shock Proteins Is a Putative Target for the Immunosuppressant 15‐Deoxyspergualin -- Effects of 15‐Deoxyspergualin on the Expression of Surface Immunoglobulin in 70Z/3.12 Murine Pre‐B Cell Line ━ Part IV. Guanine Arabinoside and Purine Nucleoside Phosphorylase Inhibitors: Enzymes of the Purine Metabolism: Inhibition and Therapeutic Potential -- IMP Dehydrogenase Inhibitors as Immunomodulators -- Guanine Arabinoside as a Bone Marrow‐Purging Agent -- Application of X‐Ray Crystallographic Methods in the Design of Purine Nucleoside Phosphorylase Inhibitors -- Activities of Two 9‐Deazaguanine Analogue Inhibitors of Purine Nucleoside Phosphorylase, CI‐972 and PD 141955, in Vitro and in Vivo
━ Part V. Immunomodulating Activity of Experimental Therapeutics: Levamisole‐Induced Neopterin Synthesis -- Experimental Modulation of IL‐1 Production and Cell Surface Molecule Expression by Levamisole -- Recent Clinical Trials with Levamisole -- Sex Hormones as Immunomodulators of Disease -- Corticosteroids as Immunomodulators -- Androstenediol Regulates Systemic Resistance against Lethal Infections in Mice -- Overview on the Chemistry and Immunomodulating Properties of Novel Pyrimidinones -- Bropirimine in Bladder Cancer: Clinical Studies -- Immunosuppressive Activity of Mycophenolate Mofetil -- Molecular Mechanisms of Immunosuppression by Cyclosporins -- Study of the Immunosuppressive Properties of Cyclosporine Analogues -- Suppression of Alloantigen Presentation by Prodigiosin, a T Cell‐Specific Immunosuppressant -- In Vivo and in Vitro Efficacy of Fusidic Acid in HIV Infection -- In Vivo Antitumor Activity of the Hypoxanthine Derivatives ST 789 and ST 689 -- Syntheses of Macromolecular Immunomodulators and Conjugates Employing Haloacetyl Reagents -- Immunomodulating Activity of Myelopeptides: Clinical Trials -- Structural Nature and Functions of Transfer Factors -- Effect of Oral Administration of Heat‐Killed Enterococcus faecalis FK‐23 on the Leukocyte‐Reconstituting Capacity in Immunosuppressed Dogs -- Antitumor and Antimicrobial Activities of Enterococcal Preparation Orally Administered to Mice -- Immunostimulating Peptide Derived from Soybean Protein -- Two Simple Glucose Derivatives with Opposite Immunoactivities -- Immunopharmacologic Study of Glucofructan from Symphytum asperum Roots ━ CONFERENCE LECTURESHIPS: The Edmrd Jenner Lecture: Biological Spinoffs of Organ Transplantation -- The Pharmacology of Azathioprine -- Immunopathogenesis of HIV Infection -- Transcription Factors in Lymphoid Development
━ Part VI. Immunomodulating Activities of Anti‐Infectious Drugs: Immunomodulating Drugs: Whence and Whither -- Immunomodulator Effects on the Friend Virus Infection in Genetically Defined Mice -- Immunomodulating Activity of Antifungal Drugs -- Immunopharmacologic Properties of Inosine 5'‐Methyl Monophosphate (MIMP) -- Immunomodulatory Properties of AZT -- Antiviral Activity of a Synthetic Double‐Stranded Polyribonucleotide Interferon Inducer in a Murine AIDS Retrovirus Model Role of Augmentation of Natural Killer Cell Activity and Synergy with Oral AZT ━ Part VII. Treatment of Infectious Diseases and Sepsis: Intervention by Immune Regulation: Modulation of Cytokine Responses in Sepsis -- Interventions for the Treatment of Septic Shock -- Pleiotropic Effects of Transforming Growth Factor‐β on Cells of the Immune System -- TGFβ and HIV Infectiona
━ Part VIII. Immunomodulating Properties of Peptides in Allergic and Autoimmune Diseases: Cytokines and Modulation of Diseases of Immediate Hypersensitivity -- Therapeutic Peptides That Block Interaction of T Cells with MHC in Experimental Allergic Encephalomyelitis --Antigen Presentation by the Murine Renal Proximal Tubule: A Mechanism of Self Tolerance? ━ Part IX. Kamp Medicine (Japanese Herbal Medicine) and Its Imrnunomodulating Effects with Special Reference to Intractable Asthma: Immunologic Aspects of Kampo Medicine -- Inhibition of Hypersensitivity Reactions by Saiboku‐to (TJ‐96), Particularly on Type IV Reaction -- Effect of Saiboku‐to (TJ‐96) on Bronchial Asthma Induction of Glucocorticoid Receptor, β–Adrenaline Receptor, IgE‐Fce Receptor Expression and Its Effect on Experimental Immediate and Late Asthmatic Reaction -- Effect of an Herbal Preparation, Saiboku‐to (TJ‐96), on Antigen‐Induced Airway Hyperresponsiveness and Eosinophil Infiltration in Actively Sensitized Guinea Pigs -- Effects of Saiboku‐to (TJ‐96) on the Production of Platelet‐Activating Factor in Human Neutrophils -- A Multicenter Clinical Trial of TJ‐96 in Patients with Steroid‐Dependent Bronchial Asthma A Comparison of Groups Allocated by the Envelope Method ━ Part X. Cytokines and Regulation of the Immune Response: Cytokines and Their Role as Growth Factors and in Regulation of Immune Responses -- The Interleukin‐2 Receptor: A Target for Immunotherapy -- The Role of the T Cell Receptor α Chain in Antigen‐Specific Immune Suppression -- Increased Levels of Leukotriene B4 and Interleukin‐8 in Psoriatic Skin -- NK Cells and Interferon as Mediators of Biological Response Modifier‐Mediated Protection against MCMV and HSV‐2 Infection in Normal and Immunocompromised Mice
━ Part XI. Drug Metabolizing Enzymes and the Immune System: Immune Dysfunction Related to Drug‐Metabolizing Enzymes -- Role of the Ah Receptor and the Dioxin‐Inducible [Ah] Gene Battery in Toxicity, Cancer, and Signal Transduction -- Autoantibodies against Cytochromes P‐450 in Drug‐Induced Autoimmune Hepatitis -- Immunity to Halothane Metabolite‐Modified Proteins in Halothane Hepatitis -- Effects of Small Doses of Dioxins on the Immune System of Marmosets and Rats ━ Part XII. Novel Strategies for Immunotherapy: Immunologic Approaches to the Therapy of HIV‐1 Infection -- Gene Transfer for Therapy and Prophylaxis of HIV‐1 Infection -- Modulation of Macrophage Function by Transforming Growth Factor β, Interleukin‐4, and Interleukin‐10 -- Pseudomonas Exotoxin and Recombinant Immunotoxins Derived from It -- Superantigens in Infectious Diseases, Including AIDS -- RNA Drug Therapy Acting via the 2–5A Synthetase/RNase L Pathway -- Specific RNA Drug Therapy of Hepatitis Viruses -- Immunorehabilitation in Patients with Herpes Simplex -- Quantitative Determination of HLA‐DR Antigen Expression on Cell Surfaces with Monoclonal Antibody by Dot‐ELISA -- Role of Increase of Opiod Receptors in Granulocyte CDllb/CD18 Dysfunction -- Immunosuppressive Effects of Lymphocyte‐Specific Histamine Congener Treatment of an Adoptive Transfer Model ━ Part XIII. Vaccines: Recent Progress in Development: Issues in the Development of a Prophylactic HIV Vaccine -- T Cell Vaccines for Autoimmune Diseases -- Vaccines Based on Synthetic Polyions and Peptides -- Advances in Influenza Virus Vaccine Research
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Autor secundario Georgiev, Vassil St., ed. lit.
Yamaguchi, Hideyo, ed. lit.
New York Academy of Sciences, ed.
ISBN 0897667719